Novel Protein Precipitation Method for Whole Blood Using Automated Tip-on-Tip TechnologyCarmen Adamson
- Introduce innovative automated multi-purpose INTip filtration technology
- Demonstrate the feasibility of a novel and rapid protein precipitation method, often referred to as “protein crash”.
- This method can be extended to many areas of science, including drug discovery, metabolomics, and clinical trial studies.
- This automated procedure could be applied to applications such as gelatin removal from drug formulations or processing cell lysates.
All sample preparation was performed on a Hamilton NIMBUS96 platform.
This study shows that efficient protein precipitation using an automated liquid handler with simple pipetting commands can be substituted for laborious vortex mixing.