Our patent-pending size exclusion chromatography product line can be used for desalting and buffer exchange: a group separation method where small molecules (such as salts) are separated from a group of larger molecules (such as proteins.) Samples can be quickly prepared for other downstream chromatography techniques and assays. Our unique INTip swelling method, for the column packing, prepares the gel resin bed for sample loading in less than 20 minutes.
Size exclusion chromatography pipette tips provide a solution for automating desalting and buffer exchange without the need for centrifugation or positive pressure manifolds. The present device and methods were developed to overcome the complexities and time commitment of manual column preparation and centrifugation steps.