FAQ
Dispersive Pipette XTRaction technology introduces the benefits of solid phase extraction into a revolutionary, easy-to-use pipette tip. This device is unique from fixed-bed resin formats because sorbent material is loosely contained within a tip.
XTRactions are fast! Depending on the application, our customers typically find that extraction time is significantly reduced when compared to traditional SPE. XTR tips are designed to work seamlessly on robotic liquid handlers, unlike conventional SPE.
The disperser helps to perturb the sample solution and loose sorbent during aspirate and dispense steps. This mixing provides a highly efficient interaction of the sorbent and sample solution resulting in ideal analyte recoveries and reduced matrix effects. You can seamlessly integrate XTR tips with any workflow or method.
INTip SPE
Barrier
Disperser
Loose Sorbent
Frit
• XTR Tip Anatomy
• Cleanup Workflow
• Bind-Wash-Elute Workflow
• XTR on Hamilton Robotics
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| Dispersive XTRaction | SPE Cartridge | 96-well plate | |
|---|---|---|---|
| Customization | |||
| High efficiency | |||
| Low sample volumes | |||
| Reduced solvent volumes | |||
| Scalable Process 1 - 96 | |||
| Automation | |||
| No hardware required |
While “dilute and shoot” methods are often perceived as “inexpensive” and “rapid”, our customers frequently tell us that they have had to purchase high-end ultra-sensitive instrumentation in order to achieve the desired analytical outcomes. By placing strategic emphasis on sample preparation (i.e. “the front end”), significantly higher costs associated with more expensive LC-MS/MS instrumentation may be unnecessary.
Dispersive Pipette XTRaction produces cleaner extracts
Cleaner extracts lead to less LC-MS/MS maintenance, fewer repeat sample injections and reduced data analysis time.
Reduce solvent volumes and waste generation. LC column life is extended
A customized product for your application
XTR tips are manufactured to order per custom specifications. Tips can hold 1 – 100 mg of sorbent depending on the tip format.
You can choose your chemistry to meet any unique selectivity for the diverse range of analytes.
- RP
- WAX
- WCX
- SCX
- SAX
- Silica
- C18
- HybridSPE® – Phospholipid removal
- Mixed Mode – combine chemistries in custom amounts ex. WAX/RP
- DPX +SALLE – add Salt for a novel cleanup mechanism ex. WAX-S, RP-S
Whether you are in the early stages of method development with a new application or seeking to enhance current throughput, DPX offers a solution!
Replace your current SPE or purification methods
Ideal when looking for high throughput, automation and ease of use.
Improve your current SPE or purification methods
- Resolve current issues with a DPX solution
- Reduce sample volumes
- Cleaner extracts
- Reduce costs
Develop new methods
- Design of experiments
- Identify matrix, analytes, and necessary concentration/ dilution factors
We’ve designed a workflow graphic to demonstrate the utility of DPX technology for sample preparation and purification for a variety of matrices and applications.
We routinely develop custom solutions. We work with you to determine the best DPX product to recommend. We do our best to understand your current issues and develop a new solution. The graphic below demonstrates how we can help you find the right DPX product.
For R&D support or custom method development please contact us.
DPX purification products are routinely used in a variety of applications for clinical laboratory medicine, forensic toxicology, food safety analysis and proteomics/ genomics sample preparation.
We’ve put together some examples of matrices, but don’t hesitate to contact us about your sample purification needs if you don’t see your matrix listed!
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Certainly! DPX Technologies has been recognized for its outstanding on-site customer support. We provide confidential and customized technical assistance with method development and/or validation as you incorporate our products into your workflow. Contact us to discuss this program.
Yes! It is very important to us that customers validate our products in their laboratories. DPX technology continues to be highlighted in a number of peer-reviewed publications and presentations. Visit our resources page to look through applications by industry.
Absolutely! We have partnered with a number of leading manufacturers in order to provide customized high-throughput solutions.
Dispersive Pipette XTRaction
XTR tips are compatible with most automated and semi-automated liquid handlers.
Tip-on-Tip
Filtration Tips for ToT methods are currently available on Hamilton and Integra platforms.