What makes Dispersive Pipette XTRaction technology advantageous when compared to traditional SPE methods?2019-12-19T18:00:20+00:00

Dispersive Pipette XTRaction technology introduces the benefits of solid phase extraction into a revolutionary, easy-to-use pipette tip. This device is unique from fixed-bed resin formats because sorbent material is loosely contained within a tip.

XTRactions are fast! Depending on the application, our customers typically find that extraction time is significantly reduced when compared to traditional SPE. XTR tips are designed to work seamlessly on robotic liquid handlers, unlike conventional SPE.

The disperser helps to perturb the sample solution and loose sorbent during aspirate and dispense steps. This mixing provides a highly efficient interaction of the sorbent and sample solution resulting in ideal analyte recoveries and reduced matrix effects. You can seamlessly integrate XTR tips with any workflow or method.


XTR - Universal style 1 mL tip



Loose Sorbent


• XTR Tip Anatomy

• Cleanup Workflow

• Bind-Wash-Elute Workflow

• XTR on Hamilton Robotics

Click links to sort the slider!

High efficiency
Low sample
Reduced solvent
Process 1 - 96
No hardware

Aspirate Sample

Easy Sample Cleanup

Mix sample via aspirate and dispense steps

Interferents Bind to Sorbent

Dispense Analyte
of Interest

  • No vacuum manifold
  • Unparalleled ease of use
  • Low cost, automated solution
  • Custom method development

Bind - Wash - Elute



Disperser forces turbulent mixing of loose sorbent

Interferents Wash Off

Elute Analyte of Interest

Analyte Binds
to Sorbent



  • Rapid extraction times
  • Higher analyte recoveries
  • Sorbent chemistry customization
Our lab uses dilute and shoot methods why would we use Dispersive Pipette XTRaction technology?2019-12-19T18:00:04+00:00

While “dilute and shoot” methods are often perceived as “inexpensive” and “rapid”, our customers frequently tell us that they have had to purchase high-end ultra-sensitive instrumentation in order to achieve the desired analytical outcomes. By placing strategic emphasis on sample preparation (i.e. “the front end”), significantly higher costs associated with more expensive LC-MS/MS instrumentation may be unnecessary.

Dispersive Pipette XTRaction produces cleaner extracts

Cleaner extracts lead to less LC-MS/MS maintenance, fewer repeat sample injections and reduced data analysis time.

Reduce solvent volumes and waste generation. LC column life is extended

A customized product for your application

XTR tips are manufactured to order per custom specifications. Tips can hold 1 – 100 mg of sorbent depending on the tip format.

You can choose your chemistry to meet any unique selectivity for the diverse range of analytes.

  • RP
  • WAX
  • WCX
  • SCX
  • SAX
  • Silica
  • C18
  • HybridSPE® – Phospholipid removal
  • Mixed Mode – combine chemistries in custom amounts ex. WAX/RP
  • DPX +SALLE – add Salt for a novel cleanup mechanism ex. WAX-S, RP-S



How can we integrate DPX products into our workflow?2019-12-19T17:59:46+00:00

Whether you are in the early stages of method development with a new application or seeking to enhance current throughput, DPX offers a solution!

Replace your current SPE or purification methods

Ideal when looking for high throughput, automation and ease of use.

Improve your current SPE or purification methods

  • Resolve current issues with a DPX solution
  • Reduce sample volumes
  • Cleaner extracts
  • Reduce costs

Develop new methods

  • Design of experiments
  • Identify matrix, analytes, and necessary concentration/ dilution factors

We’ve designed a workflow graphic to demonstrate the utility of DPX technology for sample preparation and purification for a variety of matrices and applications.

How can DPX products be customized to our applications?2019-12-19T17:59:00+00:00

We routinely develop custom solutions. We work with you to determine the best DPX product to recommend. We do our best to understand your current issues and develop a new solution. The graphic below demonstrates how we can help you find the right DPX product.


Sample volume/matrix?

Concentration/dilution factor?

Identify high quality sorbent

Identify sorbent amount

Solvent evaporation?

Identify elution volume

Identify DPX product

Ex. basic small molecule

Ex. 1 mg

Ex. 4 fold concentration


25 μl

Ex. 100 μl plasma
100 μL buffer

μXTR tips with 1 mg SCX sorbent
These tips are compatible with Hamilton and Integra platforms.

Ex. Strong Cation Exchange (SCX)

For R&D support or custom method development please contact us.

How do we know if DPX products can be used with our specimen matrices?2019-12-19T17:59:27+00:00

DPX purification products are routinely used in a variety of applications for clinical laboratory medicine, forensic toxicology, food safety analysis and proteomics/ genomics sample preparation.

We’ve put together some examples of matrices, but don’t hesitate to contact us about your sample purification needs if you don’t see your matrix listed!

Hover over each icon for more information!

Tap each icon for more information!

Are method development and validation assistance available on-site?2019-12-19T17:58:33+00:00

Certainly! DPX Technologies has been recognized for its outstanding on-site customer support. We provide confidential and customized technical assistance with method development and/or validation as you incorporate our products into your workflow. Contact us to discuss this program.

Have DPX applications been validated by independent laboratories?2019-12-19T17:58:22+00:00

Yes! It is very important to us that customers validate our products in their laboratories. DPX technology continues to be highlighted in a number of peer-reviewed publications and presentations. Visit our resources page to look through applications by industry.

Does DPX support high-throughput laboratories?2019-12-19T17:57:56+00:00

Absolutely! We have partnered with a number of leading manufacturers in order to provide customized high-throughput solutions.

Dispersive Pipette XTRaction

XTR tips are compatible with most automated and semi-automated liquid handlers.


Filtration Tips for ToT methods are currently available on Hamilton and Integra platforms.

Questions about scripts or automation support?

Visit our automation page to learn more about solutions we have for specific liquid handlers.

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