Development and Validation of LC/QTOF Drug Screening Method for Over 375 Drugs in Blood Using Size Exclusion Chromatography (SEC) Tips

HIGHLIGHTS: Improved sensitivity, reduced sample volume

In forensic toxicology, the drug screening process is a critical component of case examinations. Many widely used screening methodologies exhibit analytical limitations. Advancements in instrumentation have prompted a pursuit of screening techniques that offer an expanded scope, improved sensitivity and specificity, and reduced sample size, all while preserving sample integrity. By employing size exclusion chromatography (SEC), it is possible to enhance sensitivity for low-level analytes by mitigating biological matrix effects.

About SEC Tips

SEC tips incorporate a unique pipette tip design for automated group separation of complex sample mixtures and patent-pending INTip Swelling method.

Learn more about SEC tips used in this method.