Automated Sample Filtration
for Analytical Chemistry
From biological sample to LC-MS ready sample
in minutes with reduced matrix effects
Anatomy of INTip Filtration
Tip-on-Tip Filtration provides an automated alternative to traditional centrifugation or manual filtration steps. INTip Filtration combines traditional filtration media with automation native pipette tips to simplify complex sample preparation workflows without compromising results.
The top tip aspirates a sample solution, then fits inside a Filtration tip and dispenses the sample solution through the filtration media.
Click the arrows for the slider to see a video of how this works.
What is the advantage of automated INTip filtration over traditional centrifugation or manual filtration?
- Particulate removal down to less than 1 µm
- No positive pressure/ vacuum manifold
- High-throughput workflows that can process up to 96 samples in under 2 minutes
- Low cost/ high efficiency solution
Click the applications tab to see workflows for Tip-on-Tip Filtration methods.
What applications are best for filtration tips?
High throughput filtration for biological samples and cannabis solvent extracts
Click the image lightbox to see the workflow.
High-throughput protein precipitation for blood or serum
Click the image lightbox to see the workflow
Tip-on-Tip Technology for Solid Phase Extraction and Cleanup Methods
Filtration tips can be used with sorbent chemistry for Tip-on-Tip cleanup and solid phase extraction workflows. This methodology provides an automated solution for analysis of complex viscous matrices.
Product Ordering Guide:
Application and Technical Notes
- Tip-on-Tip Urine Filtration/ Beta-glucuronidase Enzyme Removal
- Tip-on-Tip Protein Precipitation
- Automated Vitamin D Extraction from Serum
- Semi-automated Protein Precipitation Method Using Tip-on-Tip Technology and the Integra ASSIST PLUS for Analysis of Benzodiazepines in Biological Fluids
- Filtration for Cannabis Matrices
- Automated Method for High-throughput LC-MS/MS Quantitation of Testosterone from Serum: An improved Validated Method
- Sensitive Analysis of Therapeutic and Abused Drugs in Whole Blood Using Tip-on-Tip Technology with LC-MS/MS
Videos:
How to Order
Filtration tips are compatible with semi-automated and automated liquid handlers, including Hamilton Robotics and Integra Systems
For Tip-on-Tip, an automation vendor-specific tip fits within a Filtration tip with an air-tight seal.
Pipette tips for simple filtration and protein precipitation applications:
Low Porosity Filtration Tips
Dual Phase Filtration Tips
Single Phase Filtration Tips
Shown here: Top-tip Hamilton Wide bore, sold separately
Bottom tip for filtration: Dual Phase
Shown here: Top-tip Integra, sold separately
Bottom tip for filtration: Low Porosity