Which DPX product should I use with my matrix?
Use the guide to learn more about which DPX product can be used with each sample matrix. Contact us for information on custom method development.
Matrix:
Urine
Pretreatment:
Hydrolysis
Tip-on-Tip Filtration
< 2 minutes, beta-glucuronidase enzyme removal, improved dilute and shoot
OR
Dispersive Pipette XTRaction
< 10 minutes, increased sensitivity, cleanest extract
Dilute
to desired factor*
Analysis:
LC-MS
*Depending on mass spectrometer sensitivity, solvent evaporation may be required when using dispersive pipette extraction.
- Automated Extraction of Therapeutic Drugs of Abuse in Urine
- Automated Extraction of Catecholamines from Urine
- Tip-on-Tip Urine Filtration/ Beta-glucuronidase Enzyme Removal
- Analysis of Benzodiazepines in 5 different biological matrices
- Automated Method for Quantitation of Fentanyl, Norfentanyl, Buprenorphine and Norbuprenorphine in Urine
- Quantification of 11 cannabinoids and metabolites in urine
Matrix:
Oral Fluid
Tip-on-Tip Solid Phase Extraction
Ideal for the most viscous oral fluid samples.
OR
Dispersive Pipette XTRaction
Ideal when using pre-filtration.
Solvent Evaporation
Analysis:
LC-MS
Matrix:
Blood/Serum
Tip-on-Tip Protein Precipitation
Benefits: < 5 minutes, preparation straight for analysis
OPTIONAL
Dispersive Pipette XTRaction
Benefits: After ToT add cleanup or SPE for specific analytes of interest prior to analysis
Analysis:
LC-MS
- Tip-on-Tip Protein Precipitation
- Automated Vitamin D Extraction from Serum
- THC Analysis in Whole Blood
- A Sensitive LC-MS/MS Method for Analysis of Male Drug Hormones in Serum
- Semi-automated Protein Precipitation Method Using Tip-on-Tip Technology and the Integra ASSIST PLUS for Analysis of Benzodiazepines in Biological Fluids
- A Sensitive LC-MS Method for the Measurement of Nestorone in Human Serum
- Automated Method for LC-MS/MS Quantitation of Testosterone in Serum
Hair
Meconium
Tissue
Dispersive Pipette XTRaction
Benefits: Fast, easy to use, easy to automate
Analysis:
LC-MS
- Application Note: Analysis of Benzodiazepines in 5 Biological Matrices
- Application Note: Analysis of Benzodiazepines in Meconium
- JAT Article: Retrospective Analysis of Selected Opioids in Hair
- JAT Article: A Rapid Assay for Simultaneous Determination of Nicotine, Cocaine and Metabolites in Meconium
Matrix:
Cannabis
Flower, extract or edibles
Tip-on-Tip Filtration
Benefits: Particulate removal down to less than 1 μm; eliminate clogging in downstream analysis
OPTIONAL
Dispersive Pipette XTRaction
Benefits: Add cleanup or SPE to remove matrix interferences