Small Molecule Analysis: Product Guide by Matrix
Use the guide to learn more about which DPX product can be used with each sample matrix. Contact us for information on custom method development.
Matrix:
Urine
Pretreatment:
Hydrolysis
Tip-on-Tip Filtration
< 2 minutes, beta-glucuronidase enzyme removal, improved dilute and shoot
OR
Dispersive Pipette XTRaction
< 10 minutes, increased sensitivity, cleanest extract
Dilute
to desired factor*
Analysis:
LC-MS
*Depending on mass spectrometer sensitivity, solvent evaporation may be required when using dispersive pipette extraction.
Matrix:
Oral Fluid
Tip-on-Tip Solid Phase Extraction
Ideal for the most viscous oral fluid samples.
OR
Dispersive Pipette XTRaction
Ideal when using pre-filtration.
Solvent Evaporation
Analysis:
LC-MS
Matrix:
Blood/Serum
Tip-on-Tip Protein Precipitation
Benefits: < 5 minutes, preparation straight for analysis
OPTIONAL
Dispersive Pipette XTRaction
Benefits: After ToT add cleanup or SPE for specific analytes of interest prior to analysis
Analysis:
LC-MS
Hair
Meconium
Tissue
Dispersive Pipette XTRaction
Benefits: Fast, easy to use, easy to automate
Analysis:
LC-MS
Matrix:
Cannabis
Flower, extract or edibles
Tip-on-Tip Filtration
Benefits: Particulate removal down to less than 1 μm; eliminate clogging in downstream analysis
OPTIONAL
Dispersive Pipette XTRaction
Benefits: Add cleanup or SPE to remove matrix interferences
