Dr. Brewer originated the idea for a solid-phase extraction device while working for the S.C. Law Enforcement Division as a forensic toxicologist. His goal was to streamline sample preparation by transferring liquid samples and performing extractions within a pipette tip. Dr. Brewer obtained a patent for a “Disposable Pipette Extraction” (DPX) device in 2000. This flagship technology has since been rebranded as Dispersive Pipette XTRaction.
The device is unique from all other SPE devices because sorbent material is loosely contained between two barriers within a pipette tip. Product development continued with pipette tips for automated liquid handlers. Since automation tips had a narrow design for 96 well plates Dr. Brewer modified the device to increase extraction efficiency and reproducibility using a “disperser”. Pipette tips now contain a disperser that forces turbulent mixing of the loose sorbent and sample solution during aspirate and dispense steps. In 2017, a U.S. Patent for Dispersive Pipette Extraction was allowed.
The term “disposable” inevitably did not capture the essence of the product utility. The terminology was rebranded to specify the technology for the device to be known as Dispersive Pipette XTRaction. Prior to the rebrand several published journal articles refer to the technology as Disposable Pipette Extraction. Journal articles for various applications can be found below.