Prevent Sample Failures and Remove Variability in Bioanalytical Sample Prep

Dispersive XTRaction

  • Customization

  • High efficiency

  • Low sample volumes

  • Reduced solvent volumes

  • Scalable
    Process 1- 96 samples

  • Automation

  • No hardware required

SPE Cartridge

Sample, wash and elution solvents flow through the sorbent in one direction. SPE cartridges are not automation compatible.

SPE 96- well plate

Sample, wash and elution solvents flow through the sorbent in one direction. 96-well plates do offer automation, but additional hardware like a vacuum or positive pressure manifold is required.

INTip Solid Phase Extraction (aka pipette tip SPE) utilizes a patented technology known as Dispersive Pipette XTRaction. This device is unique from all other SPE devices because sorbent is loosely contained within a pipette tip. The disperser in XTR tips helps to perturb the sample solution and loose sorbent during aspirate and dispense steps. This mixing provides a highly efficient interaction of the sorbent with the analyte of interest resulting in ideal analyte recoveries.

There are other pipette tip products for solid phase extraction on the market. Some have fixed-bed sorbent formats that still only allow a solution to flow through in one direction, similar to an SPE cartridge. Dispersive Pipette XTRaction technology has been featured in a number of publications that show-case high recoveries and reduced matrix effects in various applications for biological sample matrices. Extraction takes seconds and entire workflows can be automated and completed for some applications in less than five minutes. Moreover pipette tip solid phase extraction is very cost-effective because a significant amount of sorbent and solvents can be saved. Our Dispersive Pipette XTRaction methods have shown to achieve high sensitivity even for low sample volumes and low concentration of the analyte.

  • Pipette tips are easy-to-use and easy-to-automate!
  • Remove variability
  • Reduce failure rates
  • Reduce reanalysis
  • High recoveries
  • Sorbent customization
  • Optimized high throughput workflows
  • Increased reproducibility

Better SPE for your workflow conditions:

XTR tips are available in the largest range of pipetting platforms. SPE sorbent is available in a range phases to suit a multitude of bioanalysis applications. Choose from:

Not sure which SPE sorbent to order or how much you need in your tip?

One of our application scientists will send you a recommended protocol. We also offer confidential onsite method development.

  • Sorbent available in custom amounts. Please let us know which sorbent and how much you want in your tip.

XTR Resources:

Generic Protocols for Common Extraction Methods

We put together a series of videos on how to use XTR tips for common extraction methods. The series includes:

  2. Comprehensive Extraction of Drugs and Metabolites from Urine
  3. Rapid Cleanup
  4. DPX + SALLE

Use the guide to learn more about which DPX product can be used with each biological sample matrix. Applications are organized by sample matrix including:

  • Urine
  • Blood
  • Oral fluid
  • Hair
  • Meconium
  • Tissue
  • Cannabis

Our pipette tips are compatible with most automated liquid handlers. Seamless integration onto ALH systems promotes reduced hands-on-time, increased reproducibility and maximum throughput.