INTip Solid Phase Extraction (aka pipette tip SPE) utilizes a patented technology known as Dispersive Pipette XTRaction. This device is unique from all other SPE devices because sorbent is loosely contained within a pipette tip. The disperser in XTR tips helps to perturb the sample solution and loose sorbent during aspirate and dispense steps. This mixing provides a highly efficient interaction of the sorbent with the analyte of interest resulting in ideal analyte recoveries.
There are other pipette tip products for solid phase extraction on the market. Some have fixed-bed sorbent formats that still only allow a solution to flow through in one direction, similar to an SPE cartridge. Dispersive Pipette XTRaction technology has been featured in a number of publications that show-case high recoveries and reduced matrix effects in various applications for biological sample matrices. Extraction takes seconds and entire workflows can be automated and completed for some applications in less than five minutes. Moreover pipette tip solid phase extraction is very cost-effective because a significant amount of sorbent and solvents can be saved. Our Dispersive Pipette XTRaction methods have shown to achieve high sensitivity even for low sample volumes and low concentration of the analyte.