Sample Preparation for Blood/Serum Matrices

Webinar On-demand

This webinar explores different strategies for sample preparation of serum for mass spectrometry analysis. We will provide method recommendations suited to sample size, analyte polarity, dilution factors, etc for a variety of applications using serum, whole blood or dried blood spots as the matrix. Automated INTip Filtration can be applied to replace offline, labor intensive centrifugation steps.


  • About DPX
  • Strategy 1: Dilute Serum followed by Microelution SPE with µXTR tips
    • µXTR chemistry options and tip styles
  • Strategy 2: “Soft Protein Precipitation” with ZnSo4 followed by ToT Filtration
    • LC-MS/MS Quantification of Testosterone in Serum
    • Sensitive LC-MS/MS Analysis of Therapeutic and Abused Drugs in Whole Blood
  • Strategy 3: Full Protein Precipitation with Tip-on-Tip followed by cleanup
    • HybridSPE® XTR tips for phospholipid removal
    • DPX + SALLE

Request a Sample

Evaluate XTR tips with the chemistry you need for solid phase extraction. If you know exactly what options you want, fill out the product ordering form and specify your request.